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Fe
Minerals
Iron (Elemental)
Supplement primarily when deficiency is confirmed; overdoses can be dangerous.
What it is
Iron is essential for hemoglobin and oxygen transport. Supplementation is most appropriate with confirmed deficiency or clinician-directed need.
How it works
Supports hemoglobin/myoglobin; excess supplemental iron causes GI injury and oxidative stress.
What the evidence says
Strong for treating iron deficiency; unnecessary supplementation adds risk without benefit.
Safety Notes
- UL is 45 mg/day for adults; therapeutic deficiency dosing may exceed UL under supervision.
- Use caution with: hemochromatosis, iron overload disorders.
- levothyroxine: Reduces absorption/effect; separate by ~4h.
- proton pump inhibitors: May reduce absorption and blunt response in deficiency.
Timing With Other Supplements
- Calcium (Supplemental): Can reduce iron absorption; separate ~2h.