PQQ (Pyrroloquinoline Quinone)
Mitochondrial biogenesis activator and neuroprotective antioxidant.
By Suplagen Team · Updated
What it is
PQQ is a redox cofactor that promotes mitochondrial biogenesis through PGC-1α activation. It protects mitochondria from oxidative damage.
How it works
Activates PGC-1α signaling to stimulate new mitochondria formation; acts as a potent antioxidant with high redox cycling capacity.
What the evidence says
Emerging evidence for mitochondrial biogenesis and cognitive support; human studies are limited but promising.
How much to take
The catalog range is 10 to 20 mg daily, and 20 mg is the ceiling. The doses are small because PQQ is potent by weight; BioPQQ is the most studied branded form.
The evidence is emerging for mitochondrial biogenesis and cognitive support, with limited but promising human studies. Start at 10 mg.
When and how to take it
With food, in the morning. It's often paired with CoQ10, which the catalog lists as synergistic; the same fatty meal works for both.
Give it weeks. Mitochondrial changes aren't something you feel on day one.
Who should skip it
No contraindicated conditions and no drug interactions are listed. Pregnancy safety isn't established. Very well tolerated at catalog doses.
Safety Notes
- BioPQQ is the most studied branded form. Very well tolerated at recommended doses.
Timing With Other Supplements
- Coenzyme Q10 (CoQ10): Synergistic pairing; both support mitochondrial function.
Common questions
How much PQQ should I take?
10 to 20 mg daily with food. 20 mg is the ceiling.
When should I take PQQ?
With a meal in the morning, ideally the same meal as CoQ10 if you take both.
Does PQQ work?
The evidence is emerging: a promising mechanism and limited human trials. Reasonable as an experiment with honest expectations.